Across TCGA patient cohorts, LRRC70 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC70-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and ACC1. Each is linked with LRRC70 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC70-to-partner and partner-to-LRRC70 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC70→partner) and Y-score (partner→LRRC70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.212	-2.087	.027	.005	3	1
UCEC	eIF4G →	+0.294	+2.459	.013	.018	3	1
UCEC	ACC1 →	+0.307	+1.750	.027	.049	3	1
UCEC	MEK1 →	+0.375	+2.700	.007	.006	3	1
UCEC	mTOR_pS2448 →	-0.137	-2.446	.016	.018	3	1
UCEC	Notch1 →	+0.168	+2.087	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

LRRC70 survival (RNA) · tumor vs normal (RNA) · all LRRC70 data types