LRRC7

Across TCGA patient cohorts, LRRC7 mutation is significantly associated with the RNA expression of many other genes, with 7,659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC7-associated genes across cancer lineages are POLE2, OTX1, and DTL. Each is linked with LRRC7 in more than 6 cancer types. Because this analysis shows association rather than direction, both LRRC7-to-partner and partner-to-LRRC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by LRRC7-low versus LRRC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC7→partner) and Y-score (partner→LRRC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLE2 →	+0.330	+1.121	.001	.008	2	7
COAD	OTX1 →	+0.563	+4.183	<.001	<.001	3	6
UCEC	DTL →	+0.395	+1.765	.002	<.001	3	6
BLCA	CDC7 →	+0.629	+2.159	<.001	<.001	3	6
STAD	H2AZ1 →	+0.574	+2.502	<.001	.001	3	6
COAD	PTMAP9 →	+0.648	+1.574	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,659 associations by consensus.

POLE2 by LRRC7 expression — UCEC

Explore this box plot interactively →