LRRC7

Across TCGA pan-cancer cohorts, LRRC7 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LRRC7 data layer compared with 12 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher LRRC7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LRRC7 expression acts as an unfavorable survival marker, although some lineages such as BLCA and PAAD show a favorable association.

KICH, BLCA, and PAAD are the cancer types where LRRC7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Quartile	All	0.545	0.953	.003	74	view →
BLCA	DFS	Median	III,IV	0.357	0.205	.001	49	view →
PAAD	OS	Quartile	All	0.631	0.339	.004	33	view →
SKCM	DFS	Tertile	II,III,IV	0.288	0.127	.002	32	view →
HNSC	OS	Median	All	0.260	0.493	<.001	29	view →
UCEC	OS	Quartile	All	0.809	0.902	.006	28	view →
UVM	DFS	Median	III,IV	0.261	0.723	.009	27	view →
OV	OS	Median	III,IV	0.633	0.726	.005	26	view →
UCS	OS	Quartile	II,III,IV	0.722	0.182	.003	24	view →
LGG	DFS	Tertile	All	0.456	0.320	.006	16	view →
CESC	DFS	Tertile	All	0.420	0.709	.004	14	view →
ACC	DFS	Median	All	0.606	0.841	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LRRC7–KICH (OS)

Open the KICH breakdown →