LRRC7

Across TCGA patient cohorts, LRRC7 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC7-associated genes across cancer lineages are 4E-BP1, eIF4E, and Caspase-7-cleavedD198. Each is linked with LRRC7 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRRC7-to-partner and partner-to-LRRC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by LRRC7-low versus LRRC7-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC7→partner) and Y-score (partner→LRRC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.275	+1.906	.011	.015	3	5
UCEC	eIF4E →	+0.195	+2.032	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+0.761	+1.532	<.001	.004	3	4
LUSC	C-Raf →	+0.094	+1.853	.007	<.001	3	3
STAD	EGFR_pY1068 →	-0.299	-2.459	.032	.018	3	3
STAD	FASN →	+0.317	+1.600	.035	.039	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

4E-BP1 by LRRC7 expression — STAD

Explore this box plot interactively →