LRRC7

Across TCGA cell cohorts, LRRC7 mutation is significantly associated with the RNA expression of many other genes, with 418 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC7-associated genes across cancer lineages are BBOF1, MTF2, and C12orf40. Each is linked with LRRC7 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC7-to-partner and partner-to-LRRC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BBOF1 grouped by LRRC7-low versus LRRC7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC7→partner) and Y-score (partner→LRRC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BBOF1 →	+0.750	+2.130	<.001	<.001	3	3
LARGE_INTESTINE	MTF2 →	+0.590	+2.130	<.001	<.001	3	3
SOFT_TISSUE	C12orf40 →	+0.383	+4.930	<.001	.008	3	2
SOFT_TISSUE	TAS2R38 →	+0.046	+5.369	<.001	.004	3	2
URINARY_TRACT	TRIP11 →	+0.481	+2.932	.009	.009	3	2
URINARY_TRACT	GAREM1 →	+1.465	+2.959	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 418 associations by consensus.

BBOF1 by LRRC7 expression — LARGE_INTESTINE

Explore this box plot interactively →