LRRC7

Across TCGA cell cohorts, LRRC7 mutation is significantly associated with the mutation status of many other genes, with 3,946 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC7-associated genes across cancer lineages are LAMA1, CUBN, and KLHL36. Each is linked with LRRC7 in more than 5 cancer types. Because this analysis shows association rather than direction, both LRRC7-to-partner and partner-to-LRRC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAMA1 grouped by LRRC7-low versus LRRC7-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC7→partner) and Y-score (partner→LRRC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LAMA1 →	+1.870	+1.710	.003	.003	1	6
SOFT_TISSUE	CUBN →	+2.843	+4.193	.007	.007	1	6
STOMACH	KLHL36 →	+3.584	+3.584	.006	.006	1	6
SOFT_TISSUE	ACAN →	+3.066	+4.369	.005	.005	1	6
CNS	CDC42BPG →	+4.347	+3.862	.001	.001	1	6
CNS	PCDHA5 →	+3.025	+3.139	.009	.009	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,946 associations by consensus.

LAMA1 by LRRC7 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →