LRRC63

Across TCGA patient cohorts, LRRC63 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC63-associated genes across cancer lineages are ERK2, GAPDH, and Heregulin. Each is linked with LRRC63 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC63-to-partner and partner-to-LRRC63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by LRRC63-low versus LRRC63-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC63→partner) and Y-score (partner→LRRC63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.293	+2.321	.002	.035	3	1
UCEC	GAPDH →	+0.567	+3.169	.035	.019	3	1
UCEC	Heregulin →	-0.181	-2.321	.003	.034	3	1
UCEC	ACVRL1 →	-0.186	-2.980	.006	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.235	-2.308	.005	.036	3	1
UCEC	JNK2 →	+0.263	+2.321	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ERK2 by LRRC63 expression — UCEC

Explore this box plot interactively →