LRRC63

Across TCGA pan-cancer cohorts, LRRC63 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of LRRC63’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LRRC63 RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC63 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and LUAD are the cancer types where LRRC63 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC63 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−0.434	<.001	10	view →
LUSC	Male	II,III,IV	−0.421	<.001	9	view →
LUAD	Female	II,III,IV	−0.410	<.001	6	view →
BRCA	Female	II,III,IV	+0.159	.015	4	view →
KIRC	Female	All	−0.125	.012	3	view →
LIHC	All	All	+0.106	.001	3	view →
PRAD	All	All	+0.172	.041	2	view →
BLCA	All	III,IV	+0.232	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

LRRC63–KICH

Open the KICH breakdown →