LRRC63

Across TCGA cell cohorts, LRRC63 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,437 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LRRC63-associated GO terms across cancer lineages are Regulation of chromosome separation, Regulation of mitotic sister chromatid separation, and Positive regulation of metaphase/anaphase transition of cell cycle. Each is linked with LRRC63 in more than 8 cancer types. Because this analysis shows association rather than direction, both LRRC63-to-partner and partner-to-LRRC63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome separation grouped by LRRC63-low versus LRRC63-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC63→partner) and Y-score (partner→LRRC63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of chromosome separation →	+0.111	+0.143	.002	.009	3	8
LUNG_NSCLC_LUAD	Regulation of mitotic sister chromatid separation →	+0.063	+0.188	.003	.006	2	9
LUNG_NSCLC_LUAD	Positive regulation of metaphase/anaphase transition of cell cycle →	+0.102	+0.212	<.001	.002	3	7
URINARY_TRACT	Positive regulation of chromosome separation →	+0.112	+0.093	.002	.007	3	7
CNS	DNA biosynthetic process →	+0.045	+0.145	<.001	.004	3	7
SKIN	Kidney development →	-0.054	-0.340	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,437 associations by consensus.

Regulation of chromosome separation by LRRC63 expression — URINARY_TRACT

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