LRRC63

Across TCGA cell cohorts, LRRC63 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LRRC63-associated genes across cancer lineages are C10orf53, PRSS58, and TBC1D21. Each is linked with LRRC63 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC63-to-partner and partner-to-LRRC63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf53 grouped by LRRC63-low versus LRRC63-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC63→partner) and Y-score (partner→LRRC63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	C10orf53 →	+0.023	+4.906	<.001	.006	3	1
SKIN	PRSS58 →	+0.047	+4.977	<.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1
LUNG_NSCLC_LUAD	ADAM30 →	+0.006	+4.212	.008	.007	3	1
LUNG_NSCLC_LUAD	HMHB1 →	+0.064	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

C10orf53 by LRRC63 expression — OESOPHAGUS

Explore this box plot interactively →