LRRC61

Across TCGA patient cohorts, LRRC61 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC61-associated genes across cancer lineages are C-Raf, Ku80, and MEK1. Each is linked with LRRC61 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC61-to-partner and partner-to-LRRC61 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by LRRC61-low versus LRRC61-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC61→partner) and Y-score (partner→LRRC61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	C-Raf →	+0.190	+3.000	.017	.036	3	2
UCEC	Ku80 →	+0.273	+3.183	.035	.010	3	1
UCEC	MEK1 →	+0.468	+3.169	.019	.019	3	1
UCEC	Notch1 →	+0.255	+3.013	<.001	.018	3	1
UCEC	Tuberin →	+0.425	+3.169	.004	.020	3	1
UCEC	VHL →	-1.056	-3.000	.004	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C-Raf by LRRC61 expression — SKCM

Explore this box plot interactively →