LRRC61

Across TCGA pan-cancer cohorts, LRRC61 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LRRC61 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher LRRC61 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LRRC61 expression acts as an unfavorable survival marker, although some lineages such as HNSC and STAD show a favorable association.

LIHC, HNSC, and STAD are the cancer types where LRRC61 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.580	0.775	<.001	100	view →
HNSC	OS	Tertile	III,IV	0.456	0.198	<.001	85	view →
STAD	OS	Median	All	0.744	0.583	.001	56	view →
DLBC	OS	Median	All	0.911	0.587	.001	51	view →
COAD	DFS	Median	IV	0.335	0.607	<.001	46	view →
UCEC	DFS	Tertile	All	0.918	0.860	.003	44	view →
SCLC	OS	Quartile	All	0.842	0.507	.003	40	view →
LGG	OS	Median	All	0.743	0.869	<.001	38	view →
ACC	OS	Median	III,IV	0.690	0.205	.003	36	view →
GBM	OS	Median	All	0.325	0.504	<.001	33	view →
UCS	DFS	Tertile	IV	0.996	0.580	.036	18	view →
KIRP	OS	Tertile	III,IV	0.180	0.686	.009	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LRRC61–LIHC (OS)

Open the LIHC breakdown →