LRRC61

Across TCGA cell cohorts, LRRC61 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,297 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LRRC61-associated GO terms across cancer lineages are Inhibitory synapse assembly, Positive regulation of proteasomal ubiquitin-dependent protein catabolic process, and Regulation of glucose mediated signaling pathway. Each is linked with LRRC61 in more than 8 cancer types. Because this analysis shows association rather than direction, both LRRC61-to-partner and partner-to-LRRC61 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Inhibitory synapse assembly grouped by LRRC61-low versus LRRC61-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC61→partner) and Y-score (partner→LRRC61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Inhibitory synapse assembly →	+0.120	+1.896	.002	.002	2	9
OESOPHAGUS	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.069	+1.710	.002	.001	3	7
LUNG_SCLC	Regulation of glucose mediated signaling pathway →	+0.163	+2.150	.002	.004	3	7
LUNG_SCLC	Positive regulation of glucose mediated signaling pathway →	+0.163	+2.150	.002	.004	3	7
BLOOD_Lymphoma	mRNA transcription →	+0.059	+1.265	<.001	.003	3	7
BONE	Nucleosome organization →	+0.122	+2.996	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,297 associations by consensus.

Inhibitory synapse assembly by LRRC61 expression — URINARY_TRACT

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