LRRC59

Across TCGA pan-cancer cohorts, LRRC59 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LRRC59 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LRRC59 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LRRC59 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where LRRC59 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.566	1.000	<.001	55	view →
COAD	DFS	Median	III,IV	1.000	0.894	.035	12	view →
HNSC	OS	Median	All	0.435	0.891	.024	8	view →
LUAD	DFS	Median	All	0.970	0.824	.019	5	view →
GBM	OS	Tertile	All	0.418	0.628	.015	4	view →
PDAC	OS	Tertile	III,IV	0.867	0.527	.049	2	view →
LSCC	DFS	Median	II,III,IV	0.825	0.999	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LRRC59–CCRCC (OS)

Open the CCRCC breakdown →