LRRC59

Across TCGA pan-cancer cohorts, LRRC59 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of LRRC59’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LRRC59 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC59 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where LRRC59 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC59 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.192	<.001	12	view →
KIRC	All	IV	+0.664	<.001	12	view →
BLCA	Male	IV	+1.432	<.001	11	view →
KIRP	All	II,III,IV	+1.138	<.001	11	view →
LIHC	Male	II,III,IV	+1.264	<.001	9	view →
LUAD	Female	III,IV	+1.183	<.001	9	view →
STAD	All	All	+1.049	<.001	8	view →
LUSC	Male	II,III,IV	+0.839	<.001	8	view →
COAD	Female	II,III,IV	+0.580	<.001	8	view →
THCA	All	All	−0.275	.001	7	view →
UCEC	All	II,III,IV	+1.400	<.001	6	view →
BRCA	All	III,IV	+1.264	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

LRRC59–HNSC

Open the HNSC breakdown →