LRRC59

Across TCGA cell cohorts, LRRC59 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,299 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LRRC59-associated GO terms across cancer lineages are Negative regulation of DNA-templated DNA replication, Positive regulation of nuclear cell cycle DNA replication, and Positive regulation of mitotic sister chromatid separation. Each is linked with LRRC59 in more than 10 cancer types. Because this analysis shows association rather than direction, both LRRC59-to-partner and partner-to-LRRC59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated DNA replication grouped by LRRC59-low versus LRRC59-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC59→partner) and Y-score (partner→LRRC59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of DNA-templated DNA replication →	+0.124	+0.763	.002	<.001	3	11
PANCREAS	Positive regulation of nuclear cell cycle DNA replication →	+0.142	+0.640	<.001	<.001	3	10
PANCREAS	Positive regulation of mitotic sister chromatid separation →	+0.148	+1.088	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cell cycle phase transition →	+0.104	+0.969	.001	<.001	3	10
PANCREAS	Positive regulation of chromosome separation →	+0.180	+0.931	<.001	<.001	3	10
SKIN	Positive regulation of cytokinesis →	+0.109	+0.754	.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,299 associations by consensus.

Negative regulation of DNA-templated DNA replication by LRRC59 expression — PANCREAS

Explore this box plot interactively →