LRRC52

Across TCGA pan-cancer cohorts, LRRC52 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LRRC52 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher LRRC52 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LRRC52 expression acts as an unfavorable survival marker.

THYM, KIRC, and GBM are the cancer types where LRRC52 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
KIRC	OS	Median	All	0.141	0.655	.026	12	view →
GBM	DFS	Median	All	0.043	0.257	<.001	12	view →
BLCA	DFS	Median	All	0.197	0.627	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LRRC52–THYM (OS)

Open the THYM breakdown →