LRRC4C

Across TCGA patient cohorts, LRRC4C mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC4C-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and ACC1. Each is linked with LRRC4C in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRC4C-to-partner and partner-to-LRRC4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LRRC4C-low versus LRRC4C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC4C→partner) and Y-score (partner→LRRC4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.677	+3.267	<.001	<.001	3	3
UCEC	eEF2 →	+0.282	+1.874	.016	.049	3	3
UCEC	ACC1 →	+0.331	+2.128	.005	.009	3	3
UCEC	ATM →	-0.617	-2.263	<.001	<.001	3	3
LUAD	14-3-3_beta →	-0.097	-1.974	.032	.029	3	2
LUAD	MSH6 →	+0.310	+2.247	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Caspase-7-cleavedD198 by LRRC4C expression — UCEC

Explore this box plot interactively →