LRRC4C

Across TCGA pan-cancer cohorts, LRRC4C RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LRRC4C data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher LRRC4C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC4C expression acts as an unfavorable survival marker, although some lineages such as SKCM and LGG show a favorable association.

KIRP, BLCA, and SKCM are the cancer types where LRRC4C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.786	0.936	<.001	117	view →
BLCA	OS	Median	All	0.451	0.715	.001	71	view →
SKCM	OS	Quartile	All	0.866	0.714	<.001	67	view →
LUSC	DFS	Median	II,III,IV	0.259	0.513	.001	59	view →
KIRC	OS	Median	All	0.546	0.712	<.001	52	view →
STAD	OS	Quartile	All	0.333	0.538	.006	47	view →
LGG	DFS	Median	All	0.502	0.259	<.001	45	view →
BRCA	OS	Tertile	IV	0.852	0.269	.001	40	view →
LUAD	OS	Median	II,III,IV	0.559	0.333	.003	22	view →
SARC	OS	Quartile	All	0.378	0.665	<.001	20	view →
HNSC	DFS	Tertile	III,IV	0.670	0.515	.010	20	view →
THCA	DFS	Median	III,IV	0.538	0.880	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LRRC4C–KIRP (DFS)

Open the KIRP breakdown →