LRRC4C

Across TCGA cell cohorts, LRRC4C mutation is significantly associated with the RNA expression of many other genes, with 1,306 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC4C-associated genes across cancer lineages are IFNL3, GPR75, and FAM205A. Each is linked with LRRC4C in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC4C-to-partner and partner-to-LRRC4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNL3 grouped by LRRC4C-low versus LRRC4C-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC4C→partner) and Y-score (partner→LRRC4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IFNL3 →	+0.142	+5.209	<.001	.005	3	2
LARGE_INTESTINE	GPR75 →	+0.427	+2.158	.009	.004	3	2
LARGE_INTESTINE	FAM205A →	+0.015	+2.181	<.001	<.001	3	2
URINARY_TRACT	IDI2 →	+0.025	+4.087	<.001	.009	3	1
URINARY_TRACT	SCT →	+0.114	+4.087	<.001	.009	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,306 associations by consensus.

IFNL3 by LRRC4C expression — BLOOD_Lymphoma

Explore this box plot interactively →