LRRC4B

Across TCGA patient cohorts, LRRC4B mutation is significantly associated with the RNA expression of many other genes, with 4,842 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC4B-associated genes across cancer lineages are SKA1, TOMM22, and VPS4B. Each is linked with LRRC4B in more than 4 cancer types. Because this analysis shows association rather than direction, both LRRC4B-to-partner and partner-to-LRRC4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by LRRC4B-low versus LRRC4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC4B→partner) and Y-score (partner→LRRC4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.646	+1.847	<.001	<.001	3	5
UCEC	TOMM22 →	+0.526	+2.136	<.001	<.001	3	4
UCEC	VPS4B →	+0.390	+3.584	.009	.002	2	5
UCEC	CEP55 →	+0.653	+2.502	.001	.001	3	4
UCEC	COPS3 →	+0.546	+2.115	<.001	<.001	3	4
UCEC	FXN →	+0.571	+2.818	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,842 associations by consensus.

SKA1 by LRRC4B expression — UCEC

Explore this box plot interactively →