LRRC4B

Across TCGA pan-cancer cohorts, LRRC4B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LRRC4B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LRRC4B RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC4B is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and LUSC are the cancer types where LRRC4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.841	<.001	10	view →
LUAD	Female	III,IV	−1.515	<.001	9	view →
LUSC	Female	All	−1.525	<.001	8	view →
BLCA	All	III,IV	−1.329	.014	8	view →
UCEC	All	III,IV	−2.804	<.001	6	view →
BRCA	All	II,III,IV	−0.694	<.001	6	view →
KIRC	Female	All	+0.675	<.001	6	view →
LIHC	Female	All	+0.669	<.001	6	view →
COAD	Male	All	−0.575	<.001	6	view →
HNSC	All	All	+0.263	.026	3	view →
READ	All	All	−0.646	.004	2	view →
THCA	Male	III,IV	−0.631	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LRRC4B–KICH

Open the KICH breakdown →