LRRC4B

Across TCGA patient cohorts, LRRC4B mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC4B-associated genes across cancer lineages are PDCD4, STAT3_pY705, and 4E-BP1. Each is linked with LRRC4B in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRC4B-to-partner and partner-to-LRRC4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by LRRC4B-low versus LRRC4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC4B→partner) and Y-score (partner→LRRC4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.581	-2.700	<.001	.005	3	4
UCEC	STAT3_pY705 →	-0.295	-1.807	.001	.024	3	3
UCEC	4E-BP1 →	+0.238	+1.837	.011	.014	3	3
UCEC	Cyclin-B1 →	+0.629	+3.807	.001	<.001	3	3
COAD	MIG-6 →	+0.111	+3.059	.030	.017	3	3
COAD	TSC1 →	-0.307	-2.991	.032	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PDCD4 by LRRC4B expression — UCEC

Explore this box plot interactively →