LRRC4B

Across TCGA cell cohorts, LRRC4B mutation is significantly associated with the RNA expression of many other genes, with 729 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC4B-associated genes across cancer lineages are OR6V1, IFNA8, and OR4F5. Each is linked with LRRC4B in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC4B-to-partner and partner-to-LRRC4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6V1 grouped by LRRC4B-low versus LRRC4B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC4B→partner) and Y-score (partner→LRRC4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR6V1 →	+0.026	+5.169	<.001	.001	3	2
SOFT_TISSUE	IFNA8 →	+0.034	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR4F5 →	+0.006	+5.977	<.001	.001	3	1
SOFT_TISSUE	SCGB1C1 →	+0.073	+5.977	<.001	.001	3	1
SOFT_TISSUE	MROH5 →	+0.021	+4.930	<.001	.008	3	1
PANCREAS	OPN1MW3 →	+0.013	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 729 associations by consensus.

OR6V1 by LRRC4B expression — BLOOD_Lymphoma

Explore this box plot interactively →