LRRC47

Across TCGA pan-cancer cohorts, LRRC47 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LRRC47 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher LRRC47 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC47 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where LRRC47 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.374	1.000	.004	29	view →
CCRCC	DFS	Median	II,III,IV	0.913	0.560	<.001	18	view →
GBM	OS	Quartile	All	0.975	0.764	.003	14	view →
LUAD	DFS	Median	II,III,IV	0.318	0.659	.019	4	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
HNSC	DFS	Median	III,IV	0.867	0.705	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LRRC47–LSCC (DFS)

Open the LSCC breakdown →