LRRC47

Across TCGA patient cohorts, LRRC47 mutation is significantly associated with the RNA expression of many other genes, with 1,882 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC47-associated genes across cancer lineages are RNU6-961P, UHRF1, and PLCB3. Each is linked with LRRC47 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC47-to-partner and partner-to-LRRC47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-961P grouped by LRRC47-low versus LRRC47-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC47→partner) and Y-score (partner→LRRC47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-961P →	+0.482	+5.044	<.001	.009	3	2
UCEC	UHRF1 →	+0.745	+3.332	.004	.005	3	2
UCEC	PLCB3 →	+0.534	+3.483	<.001	.002	3	2
UCEC	CENPU →	+0.814	+3.628	<.001	.001	3	2
UCEC	BUB3 →	+0.460	+3.534	.002	.002	3	2
UCEC	CXCL13 →	+1.439	+3.459	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,882 associations by consensus.

RNU6-961P by LRRC47 expression — LUAD

Explore this box plot interactively →