LRRC47

Across TCGA patient cohorts, LRRC47 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC47-associated genes across cancer lineages are INPP4B, MEK1, and Notch1. Each is linked with LRRC47 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC47-to-partner and partner-to-LRRC47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by LRRC47-low versus LRRC47-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC47→partner) and Y-score (partner→LRRC47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.578	-2.991	.002	.036	3	2
UCEC	MEK1 →	+0.379	+2.807	.017	.003	3	1
UCEC	Notch1 →	+0.205	+3.469	<.001	.002	3	1
UCEC	PCNA →	+0.216	+2.115	.022	.019	3	1
UCEC	VHL →	-0.957	-3.169	.001	.018	3	1
UCEC	Bad_pS112 →	-0.204	-3.156	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

INPP4B by LRRC47 expression — COAD

Explore this box plot interactively →