LRRC47

Across TCGA cell cohorts, LRRC47 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC47-associated genes across cancer lineages are SMIM28, RS1, and DSG4. Each is linked with LRRC47 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC47-to-partner and partner-to-LRRC47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM28 grouped by LRRC47-low versus LRRC47-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC47→partner) and Y-score (partner→LRRC47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SMIM28 →	+0.034	+4.321	.004	.009	3	1
BLOOD_Leukemia	RS1 →	+0.151	+4.149	<.001	.008	3	1
BLOOD_Leukemia	DSG4 →	+0.033	+4.269	<.001	.002	3	1
BLOOD_Leukemia	TMEM244 →	+0.271	+3.551	<.001	.009	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.008	+3.551	.007	.009	3	1
BLOOD_Leukemia	CNGB1 →	+0.065	+3.765	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

SMIM28 by LRRC47 expression — CNS

Explore this box plot interactively →