LRRC46

Across TCGA cell cohorts, LRRC46 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible LRRC46-associated genes across cancer lineages are ABCG4, MBD3L4, and PRSS58. Each is linked with LRRC46 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC46-to-partner and partner-to-LRRC46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABCG4 grouped by LRRC46-low versus LRRC46-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC46→partner) and Y-score (partner→LRRC46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ABCG4 →	+0.217	+3.285	.006	.007	3	1
LUNG_NSCLC_LUAD	MBD3L4 →	+0.011	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	PRSS58 →	+0.035	+4.266	<.001	.004	3	1
OVARY	ADAD1 →	+0.023	+5.807	<.001	.001	3	1
OVARY	OR7D4 →	+0.056	+5.196	<.001	.005	3	1
OVARY	RD3L →	+0.012	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ABCG4 by LRRC46 expression — LARGE_INTESTINE

Explore this box plot interactively →