LRRC45

Across TCGA patient cohorts, LRRC45 mutation is significantly associated with the RNA expression of many other genes, with 1,092 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC45-associated genes across cancer lineages are UBE2V1P6, MTCO3P45, and MTND4LP24. Each is linked with LRRC45 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC45-to-partner and partner-to-LRRC45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2V1P6 grouped by LRRC45-low versus LRRC45-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC45→partner) and Y-score (partner→LRRC45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	UBE2V1P6 →	+0.087	+5.676	<.001	.001	3	2
SKCM	MTCO3P45 →	+0.047	+4.282	<.001	.009	3	2
SKCM	MTND4LP24 →	+0.091	+5.634	<.001	.001	3	2
LIHC	TBC1D3F →	+0.022	+4.964	<.001	.002	3	1
LIHC	ATP5F1AP10 →	+0.020	+4.544	<.001	.009	3	1
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,092 associations by consensus.

UBE2V1P6 by LRRC45 expression — LIHC

Explore this box plot interactively →