LRRC43

Across TCGA pan-cancer cohorts, LRRC43 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated LRRC43 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LRRC43 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC43 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

HNSC, KIRP, and READ are the cancer types where LRRC43 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.696	<.001	45	view →
KIRP	DFS	Median	All	0.287	0.871	<.001	30	view →
READ	OS	Median	II,III,IV	0.054	0.934	<.001	18	view →
LUAD	OS	Median	All	0.223	0.788	.002	18	view →
COAD	OS	Median	IV	0.056	0.649	<.001	12	view →
BRCA	DFS	Median	All	0.139	0.527	.001	8	view →
UCS	OS	Median	All	0.185	0.686	.034	6	view →
LUSC	OS	Median	All	0.011	0.819	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	II,III,IV	0.795	0.558	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

LRRC43–HNSC (DFS)

Open the HNSC breakdown →