LRRC42

Across TCGA patient cohorts, LRRC42 mutation is significantly associated with the RNA expression of many other genes, with 408 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC42-associated genes across cancer lineages are MRPS31P1, RNU6-1220P, and MIR4499. Each is linked with LRRC42 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC42-to-partner and partner-to-LRRC42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS31P1 grouped by LRRC42-low versus LRRC42-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC42→partner) and Y-score (partner→LRRC42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MRPS31P1 →	+0.916	+5.324	<.001	.003	3	2
CESC	RNU6-1220P →	+0.344	+6.837	<.001	<.001	3	2
LUSC	MIR4499 →	+0.724	+4.192	<.001	.003	3	2
BRCA	SNORD116-10 →	+0.637	+5.571	<.001	.002	3	2
BRCA	RNU6-1207P →	+0.719	+5.016	<.001	.005	3	2
BRCA	MT-TD →	+0.705	+4.506	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 408 associations by consensus.

MRPS31P1 by LRRC42 expression — BRCA

Explore this box plot interactively →