LRRC41

Across TCGA pan-cancer cohorts, LRRC41 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LRRC41 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher LRRC41 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LRRC41 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where LRRC41 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	1.000	0.537	.008	28	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	25	view →
LSCC	OS	Median	All	0.913	1.000	.003	11	view →
GBM	DFS	Quartile	All	0.527	0.264	.004	8	view →
CCRCC	DFS	Tertile	IV	0.113	0.948	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LRRC41–PDAC (OS)

Open the PDAC breakdown →