LRRC41

Across TCGA pan-cancer cohorts, LRRC41 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LRRC41’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LRRC41 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC41 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, LUAD, and HNSC are the cancer types where LRRC41 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC41 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.020	<.001	12	view →
LUAD	Male	All	+0.468	<.001	11	view →
HNSC	All	All	+0.544	<.001	10	view →
LIHC	Female	II,III,IV	+0.989	<.001	9	view →
KICH	Female	All	−1.437	<.001	8	view →
LUSC	Female	All	+0.820	<.001	8	view →
COAD	All	All	+0.271	<.001	8	view →
CHOL	Female	All	+2.326	<.001	5	view →
BRCA	All	II,III,IV	+0.174	.004	4	view →
KIRP	All	IV	+0.824	.023	3	view →
STAD	Male	II,III,IV	+0.624	.015	2	view →
THCA	All	II,III,IV	−0.243	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LRRC41–KIRC

Open the KIRC breakdown →