LRRC41

Across TCGA cell cohorts, LRRC41 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,950 significant associations in total. CNS shows the largest number of these associations.

The most reproducible LRRC41-associated GO terms across cancer lineages are Negative regulation of autophagy, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, and Vesicle cargo loading. Each is linked with LRRC41 in more than 10 cancer types. Because this analysis shows association rather than direction, both LRRC41-to-partner and partner-to-LRRC41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of autophagy grouped by LRRC41-low versus LRRC41-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC41→partner) and Y-score (partner→LRRC41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of autophagy →	+0.067	+0.618	<.001	<.001	3	11
LARGE_INTESTINE	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.057	+0.792	<.001	<.001	3	11
LARGE_INTESTINE	Vesicle cargo loading →	+0.103	+0.825	<.001	<.001	3	11
CNS	Golgi vesicle transport →	+0.052	+0.479	<.001	<.001	3	11
BREAST	Organelle transport along microtubule →	+0.040	+0.466	<.001	.002	3	11
STOMACH	Positive regulation of autophagy of mitochondrion →	+0.087	+0.664	.002	.009	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,950 associations by consensus.

Negative regulation of autophagy by LRRC41 expression — LUNG_NSCLC_LUAD

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