LRRC41

Across TCGA cell cohorts, LRRC41 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC41-associated genes across cancer lineages are TERB2, C5orf52, and SIGLEC8. Each is linked with LRRC41 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC41-to-partner and partner-to-LRRC41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TERB2 grouped by LRRC41-low versus LRRC41-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC41→partner) and Y-score (partner→LRRC41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TERB2 →	+0.050	+5.087	<.001	.004	3	1
BLOOD_Leukemia	C5orf52 →	+0.036	+6.569	<.001	<.001	3	1
OVARY	SIGLEC8 →	+0.013	+5.196	<.001	.005	3	1
CNS	FGF3 →	+0.043	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TERB2 by LRRC41 expression — URINARY_TRACT

Explore this box plot interactively →