LRRC4

Across TCGA cell cohorts, LRRC4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible LRRC4-associated genes across cancer lineages are CFC1, TAFA1, and R3HDML. Each is linked with LRRC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC4-to-partner and partner-to-LRRC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFC1 grouped by LRRC4-low versus LRRC4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC4→partner) and Y-score (partner→LRRC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFC1 →	+0.019	+5.539	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
OVARY	OR13C9 →	+0.024	+4.643	.003	<.001	3	1
OVARY	OR2AK2 →	+0.074	+4.444	<.001	.001	3	1
OVARY	KRTAP10-5 →	+0.008	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CFC1 by LRRC4 expression — BLOOD_Leukemia

Explore this box plot interactively →