LRRC3B

Across TCGA patient cohorts, LRRC3B mutation is significantly associated with the RNA expression of many other genes, with 607 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC3B-associated genes across cancer lineages are RNA5SP281, SRGNP1, and MIR6075. Each is linked with LRRC3B in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC3B-to-partner and partner-to-LRRC3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP281 grouped by LRRC3B-low versus LRRC3B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC3B→partner) and Y-score (partner→LRRC3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP281 →	+0.125	+4.590	<.001	.004	3	3
UCEC	SRGNP1 →	+0.046	+4.156	<.001	.004	3	2
UCEC	MIR6075 →	+0.241	+2.223	.001	.003	3	2
UCEC	MR1 →	-0.525	-2.700	.004	.005	3	2
UCEC	DAPK3 →	+0.393	+2.202	.006	.001	3	2
READ	BPNT2P →	+0.148	+6.681	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 607 associations by consensus.

RNA5SP281 by LRRC3B expression — LUAD

Explore this box plot interactively →