LRRC3B

Across TCGA patient cohorts, LRRC3B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC3B-associated genes across cancer lineages are eEF2, JNK_pT183_Y185, and Src_pY527. Each is linked with LRRC3B in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRC3B-to-partner and partner-to-LRRC3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by LRRC3B-low versus LRRC3B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC3B→partner) and Y-score (partner→LRRC3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eEF2 →	+0.320	+2.824	.002	.001	3	4
UCEC	JNK_pT183_Y185 →	-0.210	-3.584	.001	.002	3	2
UCEC	Src_pY527 →	-0.389	-1.690	.024	.042	3	2
SKCM	Rb_pS807_S811 →	+0.354	+1.222	.011	.033	3	2
UCEC	INPP4B →	-0.312	-2.700	.016	.005	3	1
UCEC	JNK2 →	+0.189	+1.906	.018	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eEF2 by LRRC3B expression — SKCM

Explore this box plot interactively →