LRRC3B

Across TCGA cell cohorts, LRRC3B RNA expression is significantly associated with the go_rna of many other GO terms, with 195 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible LRRC3B-associated GO terms across cancer lineages are Negative regulation of sister chromatid cohesion, mRNA transport, and Regulation of blood circulation. Each is linked with LRRC3B in more than 4 cancer types. Because this analysis shows association rather than direction, both LRRC3B-to-partner and partner-to-LRRC3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of sister chromatid cohesion grouped by LRRC3B-low versus LRRC3B-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC3B→partner) and Y-score (partner→LRRC3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of sister chromatid cohesion →	+0.044	+0.634	.007	.005	3	4
BLOOD_Leukemia	mRNA transport →	+0.058	+0.603	<.001	.008	2	5
OVARY	Regulation of blood circulation →	-0.052	-0.085	.001	.008	3	4
SOFT_TISSUE	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.093	+0.113	<.001	.008	3	3
OVARY	Membrane repolarization →	-0.163	-0.058	.001	.004	3	3
BLOOD_Leukemia	Regulation of tumor necrosis factor (ligand) superfamily member 11 production →	-0.731	-0.849	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 195 associations by consensus.

Negative regulation of sister chromatid cohesion by LRRC3B expression — BLOOD_Leukemia

Explore this box plot interactively →