LRRC3B

Across TCGA cell cohorts, LRRC3B mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LRRC3B-associated genes across cancer lineages are HSFY1, TEX26, and PNMA6F. Each is linked with LRRC3B in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC3B-to-partner and partner-to-LRRC3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY1 grouped by LRRC3B-low versus LRRC3B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC3B→partner) and Y-score (partner→LRRC3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HSFY1 →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	TEX26 →	+0.035	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PNMA6F →	+0.006	+4.887	.009	.009	3	1
LARGE_INTESTINE	C6orf118 →	+0.208	+3.793	<.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
LARGE_INTESTINE	BPIFA1 →	+0.164	+4.688	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

HSFY1 by LRRC3B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →