LRRC37A6P

Across TCGA pan-cancer cohorts, LRRC37A6P RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LRRC37A6P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LRRC37A6P RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC37A6P is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, LUAD, and THCA are the cancer types where LRRC37A6P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC37A6P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.175	<.001	12	view →
LUAD	Male	III,IV	+0.993	<.001	11	view →
THCA	Male	II,III,IV	−1.271	<.001	9	view →
HNSC	All	III,IV	+0.223	.001	9	view →
STAD	Male	II,III,IV	+0.791	<.001	6	view →
LUSC	Female	All	+0.780	<.001	6	view →
LIHC	Male	All	+0.442	<.001	6	view →
COAD	All	All	+0.126	.002	6	view →
KIRP	Male	All	−0.760	<.001	5	view →
CHOL	All	All	+0.837	<.001	4	view →
BRCA	All	II,III,IV	+0.450	<.001	4	view →
BLCA	All	All	+0.212	.039	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

LRRC37A6P–KIRC

Open the KIRC breakdown →