LRRC37A3

Across TCGA patient cohorts, LRRC37A3 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC37A3-associated genes across cancer lineages are p27_pT157, eIF4E, and ERK2. Each is linked with LRRC37A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC37A3-to-partner and partner-to-LRRC37A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by LRRC37A3-low versus LRRC37A3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC37A3→partner) and Y-score (partner→LRRC37A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	p27_pT157 →	+0.097	+3.321	.017	.010	3	2
UCEC	eIF4E →	+0.166	+3.013	.012	<.001	3	2
UCEC	ERK2 →	+0.150	+2.222	.013	.009	3	2
UCEC	FoxM1 →	+0.206	+1.836	.011	.001	3	2
UCEC	JNK2 →	+0.170	+2.142	.006	.009	3	2
UCEC	Ku80 →	+0.159	+1.598	.032	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

p27_pT157 by LRRC37A3 expression — BLCA

Explore this box plot interactively →