LRRC37A3

Across TCGA cell cohorts, LRRC37A3 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC37A3-associated genes across cancer lineages are C1orf189, DAZ4, and DAZ2. Each is linked with LRRC37A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC37A3-to-partner and partner-to-LRRC37A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf189 grouped by LRRC37A3-low versus LRRC37A3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC37A3→partner) and Y-score (partner→LRRC37A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1orf189 →	+0.139	+2.791	<.001	.005	3	1
LARGE_INTESTINE	DAZ4 →	+0.123	+3.240	.004	.004	3	1
LARGE_INTESTINE	DAZ2 →	+0.127	+3.678	.004	.001	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.001	3	1
SKIN	KLHL40 →	+0.006	+4.273	<.001	.006	3	1
SKIN	OR2G6 →	+0.009	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

C1orf189 by LRRC37A3 expression — LARGE_INTESTINE

Explore this box plot interactively →