LRRC37A2

Across TCGA patient cohorts, LRRC37A2 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC37A2-associated genes across cancer lineages are ERK2, Caspase-7-cleavedD198, and Myosin-IIa. Each is linked with LRRC37A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC37A2-to-partner and partner-to-LRRC37A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by LRRC37A2-low versus LRRC37A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC37A2→partner) and Y-score (partner→LRRC37A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.347	+3.169	.001	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.796	+3.019	.014	.019	3	1
UCEC	Myosin-IIa →	+0.244	+2.814	.031	.036	1	1
UCEC	STAT3_pY705 →	-0.470	-3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ERK2 by LRRC37A2 expression — UCEC

Explore this box plot interactively →