LRRC37A2

Across TCGA pan-cancer cohorts, LRRC37A2 RNA is linked to patient survival in 31 of 34 cancer types, making it the most broadly survival-associated LRRC37A2 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LRRC37A2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC37A2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

KIRC, KICH, and KIRP are the cancer types where LRRC37A2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	II,III,IV	0.422	0.658	<.001	101	view →
KICH	DFS	Median	III,IV	0.247	1.000	.001	82	view →
KIRP	DFS	Quartile	II,III,IV	0.151	0.910	.002	58	view →
HNSC	OS	Tertile	All	0.805	0.659	.004	57	view →
ACC	DFS	Tertile	II,III,IV	0.347	0.813	.005	44	view →
SKCM	DFS	Tertile	All	0.234	0.135	.001	39	view →
BRCA	DFS	Quartile	III,IV	0.937	0.783	.002	18	view →
PAAD	OS	Median	All	0.680	0.380	.013	16	view →
UCEC	DFS	Quartile	II,III,IV	0.605	0.818	.004	16	view →
READ	OS	Median	IV	0.913	0.485	.001	16	view →
LIHC	DFS	Median	All	0.490	0.593	.013	14	view →
ESCA	OS	Quartile	IV	0.135	0.674	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 31 lineages.

LRRC37A2–KIRC (DFS)

Open the KIRC breakdown →