LRRC37A2

Across TCGA cell cohorts, LRRC37A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,620 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LRRC37A2-associated GO terms across cancer lineages are Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, Centrosome duplication, and mRNA splice site recognition. Each is linked with LRRC37A2 in more than 14 cancer types. Because this analysis shows association rather than direction, both LRRC37A2-to-partner and partner-to-LRRC37A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by LRRC37A2-low versus LRRC37A2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC37A2→partner) and Y-score (partner→LRRC37A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.150	+1.259	<.001	<.001	3	15
BONE	Centrosome duplication →	+0.104	+0.963	.006	.002	3	15
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.105	+0.732	.003	.005	3	15
STOMACH	Negative regulation of gene expression, epigenetic →	+0.087	+0.938	.001	.004	3	14
BONE	Microtubule nucleation →	+0.116	+1.074	<.001	<.001	3	14
OVARY	Centrosome cycle →	+0.080	+0.879	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,620 associations by consensus.

Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I by LRRC37A2 expression — BONE

Explore this box plot interactively →