LRRC37A2

Across TCGA cell cohorts, LRRC37A2 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC37A2-associated genes across cancer lineages are MT3, MYL10, and GZMK. Each is linked with LRRC37A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC37A2-to-partner and partner-to-LRRC37A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT3 grouped by LRRC37A2-low versus LRRC37A2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC37A2→partner) and Y-score (partner→LRRC37A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MT3 →	+1.130	+3.428	.007	.008	3	2
BLOOD_Leukemia	MYL10 →	+0.015	+4.247	<.001	.004	3	2
PANCREAS	GZMK →	+0.004	+4.029	<.001	.007	3	1
PANCREAS	CD1C →	+0.028	+3.491	<.001	.008	3	1
PANCREAS	FOXR2 →	+0.006	+4.584	<.001	<.001	3	1
URINARY_TRACT	ZNF804B →	+0.006	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MT3 by LRRC37A2 expression — STOMACH

Explore this box plot interactively →