LRRC37A

Across TCGA patient cohorts, LRRC37A mutation is significantly associated with the RNA expression of many other genes, with 273 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC37A-associated genes across cancer lineages are PGBD4P2, TAS2R16, and S100G. Each is linked with LRRC37A in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC37A-to-partner and partner-to-LRRC37A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGBD4P2 grouped by LRRC37A-low versus LRRC37A-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC37A→partner) and Y-score (partner→LRRC37A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PGBD4P2 →	+0.114	+4.822	<.001	.006	3	2
HNSC	TAS2R16 →	+0.048	+4.505	<.001	.009	3	1
HNSC	S100G →	+0.222	+4.654	<.001	.004	3	1
HNSC	RNU6-1249P →	+0.360	+6.132	<.001	.001	3	1
HNSC	RNA5SP72 →	+0.439	+4.736	<.001	.007	3	1
HNSC	RNA5SP488 →	+0.489	+4.565	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 273 associations by consensus.

PGBD4P2 by LRRC37A expression — HNSC

Explore this box plot interactively →