LRRC37A

Across TCGA pan-cancer cohorts, LRRC37A RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated LRRC37A data layer compared with 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LRRC37A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC37A expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

UCEC, MESO, and LUAD are the cancer types where LRRC37A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.648	0.824	.002	50	view →
MESO	DFS	Tertile	All	0.244	0.424	.005	47	view →
LUAD	DFS	Tertile	III,IV	0.682	0.192	<.001	42	view →
UVM	DFS	Quartile	III,IV	0.311	0.885	<.001	24	view →
KIRP	OS	Median	III,IV	0.140	0.721	.002	19	view →
ESCA	OS	Tertile	IV	0.143	0.674	.024	15	view →
PCPG	OS	Median	All	0.932	1.000	.012	13	view →
BRCA	OS	Median	III,IV	0.941	0.871	.006	13	view →
OV	OS	Median	III,IV	0.792	0.876	.005	12	view →
SKCM	OS	Median	All	0.374	0.266	.003	10	view →
THYM	DFS	Median	II,III,IV	0.901	0.583	.012	10	view →
SCLC	DFS	Tertile	II,III,IV	1.000	0.165	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

LRRC37A–UCEC (DFS)

Open the UCEC breakdown →